| 7. Round | 08/07/2022 | Boca Juniors II | - | San Lorenzo II | 2:1 | ||||
| 10. Round | 24/07/2022 | Talleres de Córdoba II | - | San Lorenzo II | 1:3 | ||||
| 12. Round | 08/08/2022 | Estudiantes II | - | San Lorenzo II | 4:2 | ||||
| 13. Round | 12/08/2022 | San Lorenzo II | - | Patronato de Paraná II | 1:2 | ||||
| 15. Round | 23/08/2022 | San Lorenzo II | - | Racing Club II | 2:0 | ||||
| 24. Round | 10/10/2022 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
| 26. Round | 18/10/2022 | San Lorenzo II | - | Sarmiento de Junín II | 0:0 | ||||
| 27. Round | 23/10/2022 | Aldosivi II | - | San Lorenzo II | 2:3 |
Argentina