| 5. Round | 06/08/2021 | Newell's Old Boys II | - | Platense II | 1:2 | ||||
| 6. Round | 16/08/2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 8. Round | 24/08/2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 9. Round | 30/08/2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 |  |
|||
| 10. Round | 03/09/2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 11. Round | 10/09/2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Round | 17/09/2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 13. Round | 24/09/2021 | Newell's Old Boys II | - | Huracán II | 2:0 | ||||
| 16. Round | 14/10/2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:1 | ||||
| 20. Round | 05/11/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 | ||||
| 22. Round | 24/11/2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 | ||||
| 23. Round | 30/11/2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 24. Round | 06/12/2021 | Newell's Old Boys II | - | Banfield II | 2:0 | ||||
| 25. Round | 10/12/2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentina