| 1. Round | 07/08/2005 | Lanús | - | Independiente | 2:4 |  |
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| 2. Round | 14/08/2005 | Independiente | - | Instituto de Córdoba | 3:0 | ||||
| 3. Round | 21/08/2005 | San Lorenzo | - | Independiente | 1:1 | ||||
| 4. Round | 28/08/2005 | Independiente | - | Argentinos Juniors | 1:1 | |
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| 5. Round | 07/09/2005 | Gimnasia de La Plata | - | Independiente | 3:0 | ||||
| 6. Round | 11/09/2005 | Independiente | - | Racing Club | 4:0 | ||||
| 7. Round | 17/09/2005 | Quilmes | - | Independiente | 1:1 | |
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| 8. Round | 25/09/2005 | Independiente | - | Tiro Federal de Rosario | 1:0 | ||||
| 9. Round | 02/10/2005 | River Plate | - | Independiente | 3:1 | ||||
| 10. Round | 05/10/2005 | Independiente | - | Newell's Old Boys | 2:0 | ||||
| 11. Round | 16/10/2005 | Banfield | - | Independiente | 2:2 | |
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| 12. Round | 22/10/2005 | Independiente | - | Colón de Santa Fe | 1:1 | ||||
| 19. Round | 14/12/2005 | Independiente | - | Rosario Central | 2:2 |  |
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