| 12. Round | 17/09/2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 18. Round | 22/10/2021 | Sarmiento de Junín II | - | Newell's Old Boys II | 1:2 | ||||
| 20. Round | 05/11/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 | ||||
| 21. Round | 17/11/2021 | Arsenal de Sarandí II | - | Newell's Old Boys II | 0:3 | ||||
| 23. Round | 30/11/2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 24. Round | 06/12/2021 | Newell's Old Boys II | - | Banfield II | 2:0 | ||||
| 25. Round | 10/12/2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentina