| 1. Round | 24/07/2021 | CF Pachuca | - | Club León | 4:0 |  |
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| 2. Round | 31/07/2021 | Mazatlán FC | - | CF Pachuca | 2:1 | ||||
| 3. Round | 10/08/2021 | CF Pachuca | - | Atlas Guadalajara | 0:1 |  |
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| 6. Round | 23/08/2021 | Gallos Blancos | - | CF Pachuca | 0:2 | ||||
| 8. Round | 14/09/2021 | CF Pachuca | - | Deportivo Toluca | 1:2 | ||||
| 9. Round | 19/09/2021 | Deportivo Guadalajara | - | CF Pachuca | 1:0 | ||||
| 10. Round | 24/09/2021 | CF Pachuca | - | Club Necaxa | 1:0 | ||||
| 11. Round | 29/09/2021 | CF Pachuca | - | CF América | 1:1 | ||||
| 12. Round | 02/10/2021 | Puebla FC | - | CF Pachuca | 1:2 |  |
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| 14. Round | 21/10/2021 | UANL Tigres | - | CF Pachuca | 3:0 | ||||
| 17. Round | 07/11/2021 | Club Tijuana | - | CF Pachuca | 3:2 |
Argentina
Chile