1. Round | 24/07/2021 | CF Pachuca | - | Club León | 4:0 | ||||
2. Round | 31/07/2021 | Mazatlán FC | - | CF Pachuca | 2:1 | ||||
3. Round | 10/08/2021 | CF Pachuca | - | Atlas Guadalajara | 0:1 | ||||
6. Round | 23/08/2021 | Gallos Blancos | - | CF Pachuca | 0:2 | ||||
8. Round | 14/09/2021 | CF Pachuca | - | Deportivo Toluca | 1:2 | ||||
9. Round | 19/09/2021 | Deportivo Guadalajara | - | CF Pachuca | 1:0 | ||||
10. Round | 24/09/2021 | CF Pachuca | - | Club Necaxa | 1:0 | ||||
11. Round | 29/09/2021 | CF Pachuca | - | CF América | 1:1 | ||||
12. Round | 02/10/2021 | Puebla FC | - | CF Pachuca | 1:2 | ||||
14. Round | 21/10/2021 | UANL Tigres | - | CF Pachuca | 3:0 | ||||
17. Round | 07/11/2021 | Club Tijuana | - | CF Pachuca | 3:2 |