| 2. Round | 19/02/2022 | Comunicaciones de Buenos Aires | - | Villa San Carlos | 1:0 | ||||
| 3. Round | 26/02/2022 | Villa San Carlos | - | CA Los Andes | 4:1 | ||||
| 4. Round | 09/03/2022 | Ituzaingó | - | Villa San Carlos | 2:0 | ||||
| 5. Round | 12/03/2022 | Villa San Carlos | - | Fénix | 0:0 | ||||
| 6. Round | 20/03/2022 | Atlético San Miguel | - | Villa San Carlos | 2:1 | ||||
| 8. Round | 03/04/2022 | Dock Sud | - | Villa San Carlos | 3:1 | ||||
| 1. Round | 06/04/2022 | Villa San Carlos | - | Cañuelas | 1:0 | ||||
| 11. Round | 23/04/2022 | Defensores Unidos de Zárate | - | Villa San Carlos | 1:1 | ||||
| 12. Round | 30/04/2022 | Villa San Carlos | - | Talleres (RdE) | 1:1 |  |
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| 13. Round | 08/05/2022 | Deportivo Merlo | - | Villa San Carlos | 1:2 |  |
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| 14. Round | 14/05/2022 | Villa San Carlos | - | Colegiales de Munro | 3:1 | ||||
| 15. Round | 21/05/2022 | Acassuso | - | Villa San Carlos | 0:1 | ||||
| 16. Round | 28/05/2022 | Villa San Carlos | - | Argentino de Quilmes | 1:2 | ||||
| 17. Round | 06/06/2022 | Justo José de Urquiza | - | Villa San Carlos | 0:4 | |
Argentina