| 8. Round | 24/08/2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 9. Round | 27/08/2021 | Arsenal de Sarandí II | - | Defensa y Justicia II | 0:1 | ||||
| 13. Round | 24/09/2021 | San Lorenzo II | - | Defensa y Justicia II | 0:2 | ||||
| 14. Round | 01/10/2021 | Defensa y Justicia II | - | Talleres de Córdoba II | 2:2 | ||||
| 15. Round | 07/10/2021 | Argentinos Juniors II | - | Defensa y Justicia II | 0:0 | ||||
| 16. Round | 13/10/2021 | Defensa y Justicia II | - | Estudiantes II | 1:2 | ||||
| 21. Round | 17/11/2021 | Unión de Santa Fe II | - | Defensa y Justicia II | 1:1 | ||||
| 22. Round | 24/11/2021 | Atlético Tucumán II | - | Defensa y Justicia II | 4:1 |
Argentina