| 1. Round | 26/07/2021 | CF Monterrey | - | Puebla FC | 1:1 | ||||
| 2. Round | 01/08/2021 | CF Monterrey | - | Pumas UNAM | 2:0 | ||||
| 3. Round | 07/08/2021 | Mazatlán FC | - | CF Monterrey | 1:1 | ||||
| 4. Round | 15/08/2021 | CF Monterrey | - | CF Pachuca | 3:1 | ||||
| 5. Round | 19/08/2021 | Cruz Azul | - | CF Monterrey | 1:1 | ||||
| 6. Round | 22/08/2021 | CF Monterrey | - | Deportivo Guadalajara | 0:0 | ||||
| 7. Round | 28/08/2021 | Club Tijuana | - | CF Monterrey | 2:2 | ||||
| 8. Round | 11/09/2021 | Atlas Guadalajara | - | CF Monterrey | 2:1 | ||||
| 9. Round | 20/09/2021 | CF Monterrey | - | UANL Tigres | 2:0 |  |
|||
| 11. Round | 23/09/2021 | CF Monterrey | - | Deportivo Toluca | 2:0 | ||||
| 10. Round | 27/09/2021 | Santos Laguna | - | CF Monterrey | 1:2 |  |
|||
| 12. Round | 02/10/2021 | FC Juárez | - | CF Monterrey | 3:1 | ||||
| 14. Round | 19/10/2021 | Gallos Blancos | - | CF Monterrey | 1:0 | ||||
| 15. Round | 23/10/2021 | CF Monterrey | - | Club Necaxa | 0:1 | ||||
| 16. Round | 01/11/2021 | Atlético San Luis | - | CF Monterrey | 1:1 | ||||
| 17. Round | 07/11/2021 | CF América | - | CF Monterrey | 0:0 |
Argentina
Italy 