| 3. Round | 27/02/2022 | Flandria | - | Chacarita Juniors | 1:2 | ||||
| 4. Round | 06/03/2022 | Guillermo Brown | - | Flandria | 1:0 | ||||
| 5. Round | 12/03/2022 | Flandria | - | Atlético Rafaela | 2:1 | ||||
| 6. Round | 19/03/2022 | Ramón Santamarina | - | Flandria | 1:1 | ||||
| 8. Round | 28/03/2022 | Atlanta | - | Flandria | 3:1 |  |
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| 9. Round | 02/04/2022 | Flandria | - | San Martín de San Juan | 4:0 | ||||
| 10. Round | 10/04/2022 | Chaco For Ever | - | Flandria | 2:2 | ||||
| 11. Round | 16/04/2022 | Flandria | - | San Telmo | 3:3 |
Argentina
Italy