| 26. Round | 04/08/2021 | Liga de Portoviejo | - | Gualaceo SC | 1:1 | ||||
| 27. Round | 11/08/2021 | Gualaceo SC | - | El Nacional | 1:0 | ||||
| 28. Round | 18/08/2021 | Gualaceo SC | - | Independiente Juniors | 2:0 |  |
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| 29. Round | 26/08/2021 | Guayaquil SC | - | Gualaceo SC | 0:2 | ||||
| 30. Round | 01/09/2021 | Gualaceo SC | - | Chacaritas FC | 0:1 | |
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| 34. Round | 29/09/2021 | Gualaceo SC | - | Liga de Portoviejo | 1:0 | ||||
| 36. Round | 13/10/2021 | Gualaceo SC | - | Atlético Santo Domingo | 1:0 |
Argentina