| 21. Round | 15/09/2021 | Palestino | - | Deportes Melipilla | 3:1 | ||||
| 24. Round | 03/10/2021 | Palestino | - | Colo-Colo | 1:2 | ||||
| 27. Round | 21/10/2021 | Universidad de Chile | - | Palestino | 0:1 | ||||
| 29. Round | 29/10/2021 | Santiago Wanderers | - | Palestino | 1:1 | ||||
| 30. Round | 04/11/2021 | Palestino | - | Unión La Calera | 1:2 | ||||
| 32. Round | 14/11/2021 | Palestino | - | Cobresal | 2:1 | ||||
| 33. Round | 28/11/2021 | Curicó Unido | - | Palestino | 1:1 |
Uruguay
USA