| 3. Round | 28/07/2021 | Godoy Cruz | - | Atlético Tucumán | 1:2 | ||||
| 4. Round | 03/08/2021 | Atlético Tucumán | - | Vélez Sarsfield | 0:0 | ||||
| 5. Round | 08/08/2021 | Gimnasia de La Plata | - | Atlético Tucumán | 1:0 | ||||
| 6. Round | 14/08/2021 | Atlético Tucumán | - | Aldosivi | 2:2 | ||||
| 7. Round | 20/08/2021 | Sarmiento de Junín | - | Atlético Tucumán | 3:0 |  |
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| 13. Round | 25/09/2021 | Banfield | - | Atlético Tucumán | 2:0 | ||||
| 14. Round | 02/10/2021 | Atlético Tucumán | - | San Lorenzo | 0:0 | ||||
| 23. Round | 29/11/2021 | Unión de Santa Fe | - | Atlético Tucumán | 3:0 | ||||
| 24. Round | 03/12/2021 | Colón de Santa Fe | - | Atlético Tucumán | 3:0 | ||||
| 25. Round | 11/12/2021 | Atlético Tucumán | - | River Plate | 1:1 |
Argentina