| 6. Round | 21/08/2021 | Atlético San Luis [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 8. Round | 10/09/2021 | FC Juárez [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 9. Round | 19/09/2021 | Cruz Azul [U20] | - | Gallos Blancos [U20] | 1:1 | ||||
| 14. Round | 19/10/2021 | Atlas Guadalajara [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 15. Round | 23/10/2021 | Deportivo Guadalajara [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 16. Round | 31/10/2021 | Cruz Azul [U20] | - | CF América [U20] | 1:1 | ||||
| 11. Round | 03/11/2021 | Cruz Azul [U20] | - | Club León [U20] | 2:0 | ||||
| 17. Round | 07/11/2021 | Pumas UNAM [U20] | - | Cruz Azul [U20] | 1:2 |
Mexico