| 7. Round | 20/09/2021 | Jong PSV | - | ADO Den Haag | 0:1 | ||||
| 9. Round | 01/10/2021 | Jong PSV | - | VVV-Venlo | 2:1 |  |
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| 12. Round | 22/10/2021 | Almere City FC | - | Jong PSV | 3:5 | ||||
| 13. Round | 01/11/2021 | Jong PSV | - | AZ Alkmaar (J) | 2:0 | |
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| 31. Round | 18/03/2022 | Jong PSV | - | Roda JC Kerkrade | 3:3 | ||||
| 32. Round | 04/04/2022 | Jong PSV | - | FC Volendam | 2:2 | |
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| 36. Round | 25/04/2022 | Jong PSV | - | MVV | 2:2 | ||||
| 37. Round | 29/04/2022 | De Graafschap | - | Jong PSV | 1:1 |
Argentina