| 6. Round | 09/07/2021 | Defensor Sporting | - | Racing | 1:4 | ||||
| 7. Round | 15/07/2021 | Villa Teresa | - | Defensor Sporting | 0:2 | ||||
| 8. Round | 22/07/2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 | ||||
| 10. Round | 05/08/2021 | Defensor Sporting | - | Rampla Juniors | 1:0 |  |
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| 15. Round | 05/10/2021 | Central Español | - | Defensor Sporting | 1:0 | ||||
| 16. Round | 12/10/2021 | Defensor Sporting | - | Atenas | 1:1 | ||||
| 17. Round | 20/10/2021 | Racing | - | Defensor Sporting | 0:1 | |
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| 18. Round | 29/10/2021 | Defensor Sporting | - | Villa Teresa | 1:2 | ||||
| 19. Round | 02/11/2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 |
Uruguay