| 2. Round | 15/01/2022 | Club Necaxa | - | CF Monterrey | 0:4 |  |
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| 4. Round | 05/02/2022 | Club Necaxa | - | CF Pachuca | 1:3 | ||||
| 5. Round | 13/02/2022 | Cruz Azul | - | Club Necaxa | 1:2 | ||||
| 6. Round | 19/02/2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 7. Round | 26/02/2022 | Club Necaxa | - | Club León | 0:1 | ||||
| 12. Round | 03/04/2022 | Club Necaxa | - | CF América | 0:1 | ||||
| 15. Round | 20/04/2022 | Club Necaxa | - | UANL Tigres | 2:0 |
Argentina