| 1. Round | 04/06/2022 | River Plate II | - | Defensa y Justicia II | 2:0 |  |
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| 2. Round | 10/06/2022 | Defensa y Justicia II | - | Lanús II | 1:0 | ||||
| 3. Round | 14/06/2022 | Huracán II | - | Defensa y Justicia II | 3:0 | ||||
| 5. Round | 27/06/2022 | Vélez Sarsfield II | - | Defensa y Justicia II | 1:2 | |
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| 6. Round | 01/07/2022 | Defensa y Justicia II | - | Gimnasia de La Plata II | 1:2 | ||||
| 9. Round | 19/07/2022 | Independiente II | - | Defensa y Justicia II | 0:0 | ||||
| 11. Round | 31/07/2022 | Arsenal de Sarandí II | - | Defensa y Justicia II | 1:1 | ||||
| 12. Round | 05/08/2022 | Defensa y Justicia II | - | Central Córdoba SdE II | 1:0 | ||||
| 17. Round | 01/09/2022 | San Lorenzo II | - | Defensa y Justicia II | 1:0 | ||||
| 20. Round | 17/09/2022 | Defensa y Justicia II | - | Estudiantes II | 0:0 | ||||
| 21. Round | 22/09/2022 | Patronato de Paraná II | - | Defensa y Justicia II | 0:4 | ||||
| 22. Round | 27/09/2022 | Defensa y Justicia II | - | Platense II | 0:1 |
Argentina