| 5. Round | 18/09/2021 | Adana Demirspor | - | Çaykur Rizespor | 3:1 |  |
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| 7. Round | 25/09/2021 | Adana Demirspor | - | Gaziantep FK | 4:0 | ||||
| 8. Round | 01/10/2021 | Antalyaspor | - | Adana Demirspor | 1:2 | ||||
| 12. Round | 07/11/2021 | Adana Demirspor | - | Hatayspor | 1:0 | ||||
| 13. Round | 21/11/2021 | Altay Izmir | - | Adana Demirspor | 1:3 | ||||
| 14. Round | 26/11/2021 | Adana Demirspor | - | Kasımpaşa SK | 0:0 | ||||
| 15. Round | 04/12/2021 | Trabzonspor | - | Adana Demirspor | 2:0 | ||||
| 16. Round | 12/12/2021 | Adana Demirspor | - | Giresunspor | 1:0 | ||||
| 21. Round | 15/01/2022 | Adana Demirspor | - | Kayserispor | 1:1 |
Turkey