| 4. Round | 27/02/2016 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 5. Round | 06/03/2016 | Racing | - | River Plate | 0:1 |  |
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| 6. Round | 20/03/2016 | River Plate | - | Plaza Colonia | 0:1 |  |
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| 7. Round | 03/04/2016 | Peñarol | - | River Plate | 0:2 | |
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| 8. Round | 10/04/2016 | River Plate | - | Juventud de Las Piedras | 0:0 | |
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| 9. Round | 24/04/2016 | Danubio | - | River Plate | 0:3 | |
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| 10. Round | 30/04/2016 | River Plate | - | CA Cerro | 3:1 | |
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| 11. Round | 08/05/2016 | Rentistas | - | River Plate | 2:1 | ||||
| 12. Round | 14/05/2016 | River Plate | - | El Tanque Sisley | 1:0 | |
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| 13. Round | 22/05/2016 | Liverpool | - | River Plate | 1:0 | ||||
| 14. Round | 29/05/2016 | River Plate | - | Defensor Sporting | 1:2 | |
Uruguay