| 10. Round | 01/10/2021 | Zagłębie Lubin | - | Jagiellonia Białystok | 0:1 | ||||
| 11. Round | 18/10/2021 | Jagiellonia Białystok | - | Radomiak Radom | 1:1 | ||||
| 12. Round | 23/10/2021 | Pogoń Szczecin | - | Jagiellonia Białystok | 4:1 | ||||
| 13. Round | 30/10/2021 | Jagiellonia Białystok | - | Piast Gliwice | 3:3 | ||||
| 15. Round | 20/11/2021 | Jagiellonia Białystok | - | Wisła Kraków | 3:1 | ||||
| 17. Round | 04/12/2021 | Jagiellonia Białystok | - | Górnik Łęczna | 1:2 | ||||
| 18. Round | 11/12/2021 | Lechia Gdańsk | - | Jagiellonia Białystok | 1:2 | ||||
| 19. Round | 18/12/2021 | Raków Częstochowa | - | Jagiellonia Białystok | 5:0 | ||||
| 20. Round | 04/02/2022 | Bruk-Bet Termalica Nieciecza | - | Jagiellonia Białystok | 2:1 | ||||
| 21. Round | 14/02/2022 | Górnik Zabrze | - | Jagiellonia Białystok | 1:2 | ||||
| 22. Round | 19/02/2022 | Jagiellonia Białystok | - | KS Cracovia | 0:0 | ||||
| 24. Round | 04/03/2022 | FKS Stal Mielec | - | Jagiellonia Białystok | 1:1 | ||||
| 25. Round | 13/03/2022 | Jagiellonia Białystok | - | Wisła Płock | 0:1 | ||||
| 34. Round | 21/05/2022 | Górnik Łęczna | - | Jagiellonia Białystok | 0:1 |  |
Poland