| 1. Round | 24/07/2021 | FC Juárez | - | Deportivo Toluca | 1:3 | ||||
| 2. Round | 01/08/2021 | Deportivo Toluca | - | UANL Tigres | 3:1 |  |
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| 3. Round | 07/08/2021 | Club Tijuana | - | Deportivo Toluca | 0:2 | ||||
| 4. Round | 15/08/2021 | Cruz Azul | - | Deportivo Toluca | 4:0 | ||||
| 5. Round | 17/08/2021 | Deportivo Toluca | - | Mazatlán FC | 2:2 | |
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| 6. Round | 21/08/2021 | Atlas Guadalajara | - | Deportivo Toluca | 0:0 | ||||
| 7. Round | 29/08/2021 | Deportivo Toluca | - | Pumas UNAM | 2:1 |
Argentina