| 2. Round | 25/07/2021 | Rosario Central | - | Vélez Sarsfield | 1:0 | ||||
| 3. Round | 28/07/2021 | Vélez Sarsfield | - | Defensa y Justicia | 0:0 | ||||
| 4. Round | 03/08/2021 | Atlético Tucumán | - | Vélez Sarsfield | 0:0 | ||||
| 5. Round | 08/08/2021 | Vélez Sarsfield | - | Colón de Santa Fe | 0:1 |  |
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| 6. Round | 14/08/2021 | River Plate | - | Vélez Sarsfield | 2:0 | ||||
| 7. Round | 21/08/2021 | Vélez Sarsfield | - | Lanús | 5:1 | ||||
| 8. Round | 25/08/2021 | Huracán | - | Vélez Sarsfield | 1:1 | ||||
| 10. Round | 07/09/2021 | Vélez Sarsfield | - | Unión de Santa Fe | 4:0 | ||||
| 13. Round | 24/09/2021 | Sarmiento de Junín | - | Vélez Sarsfield | 0:1 | ||||
| 15. Round | 09/10/2021 | Newell's Old Boys | - | Vélez Sarsfield | 1:2 | ||||
| 17. Round | 20/10/2021 | Central Córdoba SdE | - | Vélez Sarsfield | 1:2 | ||||
| 20. Round | 07/11/2021 | Vélez Sarsfield | - | San Lorenzo | 2:1 | ||||
| 25. Round | 10/12/2021 | Platense | - | Vélez Sarsfield | 3:2 |
Argentina