| 1. Round | 15/02/2021 | Estudiantes | - | River Plate | 2:1 | ||||
| 4. Round | 09/03/2021 | River Plate | - | Argentinos Juniors | 0:1 | ||||
| 5. Round | 14/03/2021 | Boca Juniors | - | River Plate | 1:1 |  |
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| 7. Round | 28/03/2021 | River Plate | - | Racing Club | 0:0 |  |
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| 9. Round | 12/04/2021 | River Plate | - | Colón de Santa Fe | 3:2 | ||||
| 10. Round | 17/04/2021 | Central Córdoba SdE | - | River Plate | 0:5 | ||||
| 11. Round | 25/04/2021 | River Plate | - | San Lorenzo | 1:2 |
Argentina