| 6. Round | 16/08/2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 7. Round | 20/08/2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 16. Round | 14/10/2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:1 | ||||
| 17. Round | 18/10/2021 | Newell's Old Boys II | - | Aldosivi II | 1:0 | ||||
| 19. Round | 29/10/2021 | Newell's Old Boys II | - | Independiente II | 1:0 | ||||
| 20. Round | 05/11/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 | ||||
| 21. Round | 17/11/2021 | Arsenal de Sarandí II | - | Newell's Old Boys II | 0:3 | ||||
| 22. Round | 24/11/2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 | ||||
| 23. Round | 30/11/2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 25. Round | 10/12/2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentina