| 1. Round | 12/02/2021 | Vélez Sarsfield II | - | Newell's Old Boys II | 3:0 | ||||
| 2. Round | 19/02/2021 | Newell's Old Boys II | - | Boca Juniors II | 1:3 | ||||
| 3. Round | 26/02/2021 | Talleres de Córdoba II | - | Newell's Old Boys II | 2:2 | ||||
| 4. Round | 05/03/2021 | Newell's Old Boys II | - | Independiente II | 1:2 | ||||
| 8. Round | 02/04/2021 | Newell's Old Boys II | - | Huracán II | 3:0 | ||||
| 10. Round | 16/04/2021 | Newell's Old Boys II | - | Patronato de Paraná II | 1:0 | ||||
| 11. Round | 23/04/2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 0:0 |
Argentina