| 7. Round | 26/09/2021 | Hatayspor | - | Fenerbahçe | 1:2 | ||||
| 9. Round | 18/10/2021 | Hatayspor | - | Gaziantep FK | 2:1 | ||||
| 11. Round | 30/10/2021 | Hatayspor | - | Beşiktaş | 1:0 | ||||
| 12. Round | 07/11/2021 | Adana Demirspor | - | Hatayspor | 1:0 | ||||
| 13. Round | 20/11/2021 | Hatayspor | - | Antalyaspor | 3:1 | ||||
| 14. Round | 28/11/2021 | Sivasspor | - | Hatayspor | 4:0 | ||||
| 15. Round | 05/12/2021 | Hatayspor | - | İstanbul Başakşehir | 0:3 | ||||
| 17. Round | 18/12/2021 | Trabzonspor | - | Hatayspor | 2:0 | ||||
| 18. Round | 22/12/2021 | Hatayspor | - | Konyaspor | 1:3 | ||||
| 19. Round | 25/12/2021 | Giresunspor | - | Hatayspor | 0:1 | ||||
| 20. Round | 08/01/2022 | Kasımpaşa SK | - | Hatayspor | 3:1 | ||||
| 26. Round | 20/02/2022 | Fenerbahçe | - | Hatayspor | 2:0 | ||||
| 36. Round | 06/05/2022 | Hatayspor | - | Trabzonspor | 1:1 | ||||
| 37. Round | 15/05/2022 | Konyaspor | - | Hatayspor | 3:1 | ||||
| 38. Round | 22/05/2022 | Hatayspor | - | Giresunspor | 4:1 |
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