| 1. Round | 08/01/2022 | Pumas UNAM [Women] | - | Club León [Women] | 1:0 | ||||
| 2. Round | 15/01/2022 | Pumas UNAM [Women] | - | CF América [Women] | 0:1 | ||||
| 3. Round | 24/01/2022 | Club Necaxa [Women] | - | Pumas UNAM [Women] | 1:0 | ||||
| 11. Round | 18/03/2022 | Pumas UNAM [Women] | - | Atlas Guadalajara [Women] | 0:0 | ||||
| 12. Round | 22/03/2022 | Mazatlán FC [Women] | - | Pumas UNAM [Women] | 0:2 | ||||
| 13. Round | 27/03/2022 | FC Juárez [Women] | - | Pumas UNAM [Women] | 1:0 |  |
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| 14. Round | 02/04/2022 | Pumas UNAM [Women] | - | UANL Tigres [Women] | 0:1 | ||||
| 15. Round | 18/04/2022 | Deportivo Guadalajara [Women] | - | Pumas UNAM [Women] | 2:1 | |
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| 16. Round | 23/04/2022 | Pumas UNAM [Women] | - | Atlético San Luis [Women] | 2:1 |  |
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| 17. Round | 02/05/2022 | Deportivo Toluca [Women] | - | Pumas UNAM [Women] | 2:3 |
Mexico