| 1. Round | 16/07/2021 | Newell's Old Boys II | - | Talleres de Córdoba II | 2:1 | ||||
| 2. Round | 23/07/2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 3. Round | 27/07/2021 | Newell's Old Boys II | - | Estudiantes II | 1:3 | ||||
| 5. Round | 06/08/2021 | Newell's Old Boys II | - | Platense II | 1:2 |  |
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| 6. Round | 16/08/2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 8. Round | 24/08/2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 16. Round | 14/10/2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:1 | ||||
| 17. Round | 18/10/2021 | Newell's Old Boys II | - | Aldosivi II | 1:0 | ||||
| 21. Round | 17/11/2021 | Arsenal de Sarandí II | - | Newell's Old Boys II | 0:3 | |
Argentina