| 2. Round | 20/09/2020 | Lamia | - | OFI Heraklion | 1:2 | ||||
| 4. Round | 04/10/2020 | PAOK Saloniki | - | OFI Heraklion | 3:0 | ||||
| 17. Round | 17/01/2021 | OFI Heraklion | - | PAOK Saloniki | 0:3 | ||||
| 19. Round | 26/01/2021 | OFI Heraklion | - | Asteras Tripolis | 0:1 | ||||
| 24. Round | 27/02/2021 | Apollon Smyrnis | - | OFI Heraklion | 2:1 | ||||
| 25. Round | 06/03/2021 | OFI Heraklion | - | AE Lárissa | 2:3 |  |
Argentina