| 1. Round | 20/07/2021 | Godoy Cruz | - | Rosario Central | 2:1 | ||||
| 4. Round | 02/08/2021 | Rosario Central | - | Aldosivi | 1:2 | ||||
| 5. Round | 06/08/2021 | Sarmiento de Junín | - | Rosario Central | 1:0 | ||||
| 6. Round | 15/08/2021 | Rosario Central | - | Independiente | 1:2 | ||||
| 9. Round | 29/08/2021 | Central Córdoba SdE | - | Rosario Central | 2:4 | ||||
| 12. Round | 20/09/2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
| 13. Round | 25/09/2021 | Talleres de Córdoba | - | Rosario Central | 4:1 | ||||
| 14. Round | 03/10/2021 | Rosario Central | - | Argentinos Juniors | 0:1 |  |
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| 16. Round | 15/10/2021 | Rosario Central | - | Patronato de Paraná | 3:2 | ||||
| 19. Round | 31/10/2021 | Unión de Santa Fe | - | Rosario Central | 3:1 |  |
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| 20. Round | 05/11/2021 | Defensa y Justicia | - | Rosario Central | 3:0 | |
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| 24. Round | 05/12/2021 | Lanús | - | Rosario Central | 2:2 |
Argentina
Italy