| 3. Round | 26/09/2021 | Boston River | - | Peñarol | 2:5 | ||||
| 4. Round | 04/10/2021 | Peñarol | - | Montevideo Wanderers | 3:0 | ||||
| 6. Round | 17/10/2021 | Deportivo Maldonado | - | Peñarol | 1:0 |  |
|||
| 7. Round | 21/10/2021 | Peñarol | - | Montevideo City Torque | 3:1 | ||||
| 8. Round | 23/10/2021 | Villa Española | - | Peñarol | 1:3 | |
|||
| 9. Round | 31/10/2021 | Peñarol | - | Nacional | 0:0 | ||||
| 10. Round | 05/11/2021 | Cerrito | - | Peñarol | 1:3 |
Argentina
