| 7. Round | 20/08/2021 | Independiente II | - | Defensa y Justicia II | 1:1 | ||||
| 10. Round | 03/09/2021 | Defensa y Justicia II | - | Central Córdoba SdE II | 0:1 | ||||
| 17. Round | 18/10/2021 | Patronato de Paraná II | - | Defensa y Justicia II | 2:2 |  |
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| 19. Round | 28/10/2021 | Racing Club II | - | Defensa y Justicia II | 2:2 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 23. Round | 30/11/2021 | Defensa y Justicia II | - | Colón de Santa Fe II | 0:2 | ||||
| 24. Round | 03/12/2021 | River Plate II | - | Defensa y Justicia II | 2:1 | ||||
| 25. Round | 09/12/2021 | Defensa y Justicia II | - | Lanús II | 2:0 |
Argentina