| 4. Round | 05/03/2021 | San Lorenzo II | - | Huracán II | 2:2 | ||||
| 7. Round | 29/03/2021 | Estudiantes II | - | San Lorenzo II | 4:1 | ||||
| 8. Round | 02/04/2021 | San Lorenzo II | - | Rosario Central II | 0:0 | ||||
| 9. Round | 09/04/2021 | Platense II | - | San Lorenzo II | 2:0 |  |
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| 12. Round | 30/04/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 13. Round | 07/05/2021 | Racing Club II | - | San Lorenzo II | 1:2 |
Argentina