| 1. Round | 12/01/2021 | UANL Tigres [Women] | - | CF Pachuca [Women] | 3:0 | ||||
| 2. Round | 16/01/2021 | Atlas Guadalajara [Women] | - | UANL Tigres [Women] | 2:1 | ||||
| 3. Round | 26/01/2021 | UANL Tigres [Women] | - | Puebla FC [Women] | 2:1 | ||||
| 4. Round | 02/02/2021 | Santos Laguna [Women] | - | UANL Tigres [Women] | 0:3 | ||||
| 5. Round | 05/02/2021 | Atlético San Luis [Women] | - | UANL Tigres [Women] | 0:0 | ||||
| 9. Round | 06/03/2021 | Pumas UNAM [Women] | - | UANL Tigres [Women] | 0:4 | ||||
| 11. Round | 16/03/2021 | CF América [Women] | - | UANL Tigres [Women] | 2:2 | ||||
| 13. Round | 30/03/2021 | CF Monterrey [Women] | - | UANL Tigres [Women] | 2:2 | ||||
| 17. Round | 04/05/2021 | Deportivo Guadalajara [Women] | - | UANL Tigres [Women] | 3:4 |
Mexico