| 1. Round | 26/07/2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 1:1 | ||||
| 2. Round | 30/07/2021 | Mazatlán FC [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 3. Round | 06/08/2021 | Mazatlán FC [U20] | - | CF Monterrey [U20] | 1:4 | ||||
| 9. Round | 18/09/2021 | Mazatlán FC [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 13. Round | 15/10/2021 | Mazatlán FC [U20] | - | Atlas Guadalajara [U20] | 3:1 | ||||
| 14. Round | 19/10/2021 | Puebla FC [U20] | - | Mazatlán FC [U20] | 2:1 | ||||
| 15. Round | 22/10/2021 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 4:0 | ||||
| 16. Round | 29/10/2021 | Club Necaxa [U20] | - | Mazatlán FC [U20] | 1:1 | ||||
| 17. Round | 05/11/2021 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 1:0 |  |
Mexico