2. Round | 26/07/2021 | Cerro Porteño | - | Libertad | 1:1 | ||||
4. Round | 08/08/2021 | Cerro Porteño | - | Guaireña FC | 2:0 | ||||
5. Round | 14/08/2021 | Club Olimpia | - | Cerro Porteño | 0:3 | ||||
11. Round | 04/10/2021 | Libertad | - | Cerro Porteño | 0:2 | ||||
13. Round | 25/10/2021 | Guaireña FC | - | Cerro Porteño | 0:2 |