| 1. Round | 23/08/2009 | Defensor Sporting | - | Atenas | 5:1 | ||||
| 2. Round | 30/08/2009 | Danubio | - | Defensor Sporting | 3:0 | ||||
| 3. Round | 13/09/2009 | Defensor Sporting | - | Nacional | 0:3 | ||||
| 4. Round | 20/09/2009 | Central Español | - | Defensor Sporting | 0:4 |  |
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| 5. Round | 27/09/2009 | Defensor Sporting | - | Fénix | 2:0 | ||||
| 7. Round | 18/10/2009 | Defensor Sporting | - | Cerrito | 1:0 |  |
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| 8. Round | 22/10/2009 | Defensor Sporting | - | Cerro Largo | 0:0 | ||||
| 9. Round | 27/10/2009 | Tacuarembó | - | Defensor Sporting | 0:1 | ||||
| 12. Round | 22/11/2009 | CA Cerro | - | Defensor Sporting | 1:4 | |
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| 13. Round | 06/12/2009 | River Plate | - | Defensor Sporting | 1:2 | ||||
| 14. Round | 09/12/2009 | Montevideo Wanderers | - | Defensor Sporting | 2:2 | |
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| 15. Round | 13/12/2009 | Defensor Sporting | - | Liverpool | 2:2 | |
Argentina