| 2. Round | 14/01/2022 | Gallos Blancos [U20] | - | Pumas UNAM [U20] | 0:1 | ||||
| 3. Round | 22/01/2022 | Deportivo Guadalajara [U20] | - | Gallos Blancos [U20] | 0:0 | ||||
| 5. Round | 14/02/2022 | CF Pachuca [U20] | - | Gallos Blancos [U20] | 2:1 |  |
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| 6. Round | 20/02/2022 | Gallos Blancos [U20] | - | Mazatlán FC [U20] | 0:0 | ||||
| 7. Round | 24/02/2022 | Gallos Blancos [U20] | - | Deportivo Toluca [U20] | 0:1 | ||||
| 8. Round | 01/03/2022 | CF América [U20] | - | Gallos Blancos [U20] | 2:0 | ||||
| 9. Round | 05/03/2022 | Gallos Blancos [U20] | - | Atlas Guadalajara [U20] | 0:1 | |
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| 11. Round | 17/03/2022 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 3:0 | ||||
| 12. Round | 03/04/2022 | Club León [U20] | - | Gallos Blancos [U20] | 2:1 | ||||
| 13. Round | 10/04/2022 | Gallos Blancos [U20] | - | UANL Tigres [U20] | 0:1 |
Mexico