| 1. Round | 13/02/2021 | Vélez Sarsfield | - | Newell's Old Boys | 1:0 |  |
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| 3. Round | 27/02/2021 | Talleres de Córdoba | - | Newell's Old Boys | 2:2 | ||||
| 4. Round | 05/03/2021 | Newell's Old Boys | - | Independiente | 1:2 |  |
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| 5. Round | 13/03/2021 | Defensa y Justicia | - | Newell's Old Boys | 4:0 | ||||
| 6. Round | 19/03/2021 | Newell's Old Boys | - | Unión de Santa Fe | 0:0 | |
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| 7. Round | 30/03/2021 | Atlético Tucumán | - | Newell's Old Boys | 2:2 | |
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| 9. Round | 12/04/2021 | Lanús | - | Newell's Old Boys | 1:3 | ||||
| 10. Round | 18/04/2021 | Newell's Old Boys | - | Patronato de Paraná | 2:0 | |
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| 12. Round | 03/05/2021 | Rosario Central | - | Newell's Old Boys | 3:0 | |
Argentina