| 1. Round | 10/01/2021 | Atlético San Luis [Women] | - | CF Monterrey [Women] | 0:5 | ||||
| 3. Round | 22/01/2021 | Cruz Azul [Women] | - | Atlético San Luis [Women] | 3:1 | ||||
| 4. Round | 31/01/2021 | Atlético San Luis [Women] | - | Club Tijuana [Women] | 3:5 | ||||
| 6. Round | 08/02/2021 | Deportivo Guadalajara [Women] | - | Atlético San Luis [Women] | 3:0 | ||||
| 8. Round | 27/02/2021 | FC Juárez [Women] | - | Atlético San Luis [Women] | 1:1 | ||||
| 10. Round | 10/03/2021 | Puebla FC [Women] | - | Atlético San Luis [Women] | 2:0 | ||||
| 11. Round | 15/03/2021 | Pumas UNAM [Women] | - | Atlético San Luis [Women] | 0:0 | ||||
| 12. Round | 21/03/2021 | Atlético San Luis [Women] | - | Santos Laguna [Women] | 2:2 | ||||
| 13. Round | 26/03/2021 | Club Necaxa [Women] | - | Atlético San Luis [Women] | 1:1 |
Mexico