| 1. Round | 06/08/2022 | Sivasspor | - | Gaziantep FK | 1:1 |  |
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| 2. Round | 14/08/2022 | Gaziantep FK | - | MKE Ankaragücü | 1:0 | ||||
| 3. Round | 20/08/2022 | Hatayspor | - | Gaziantep FK | 1:2 | ||||
| 4. Round | 26/08/2022 | Gaziantep FK | - | Antalyaspor | 5:2 | |
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| 5. Round | 05/09/2022 | Galatasaray | - | Gaziantep FK | 2:1 | ||||
| 6. Round | 11/09/2022 | Gaziantep FK | - | Ümraniyespor | 1:1 | |
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| 7. Round | 18/09/2022 | Trabzonspor | - | Gaziantep FK | 3:2 | ||||
| 9. Round | 07/10/2022 | Gaziantep FK | - | Adana Demirspor | 1:1 | |
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| 12. Round | 29/10/2022 | Alanyaspor | - | Gaziantep FK | 2:0 | ||||
| 13. Round | 06/11/2022 | Gaziantep FK | - | Kayserispor | 1:2 | ||||
| 14. Round | 13/11/2022 | Fatih Karagümrük | - | Gaziantep FK | 3:3 | ||||
| 15. Round | 25/12/2022 | Gaziantep FK | - | Beşiktaş | 1:1 | ||||
| 16. Round | 29/12/2022 | Giresunspor | - | Gaziantep FK | 2:1 | |
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| 17. Round | 05/01/2023 | Gaziantep FK | - | İstanbul Başakşehir | 1:1 | ||||
| 18. Round | 09/01/2023 | İstanbulspor AŞ | - | Gaziantep FK | 1:1 | ||||
| 19. Round | 15/01/2023 | Gaziantep FK | - | Fenerbahçe | 1:2 | |
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| 20. Round | 22/01/2023 | Gaziantep FK | - | Sivasspor | 1:2 | |
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| 21. Round | 28/01/2023 | MKE Ankaragücü | - | Gaziantep FK | 0:2 |  |
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| 22. Round | 01/02/2023 | Gaziantep FK | - | Hatayspor | 4:1 | |
Senegal
