| 1. Round | 20/07/2024 | Club Olimpia | - | Guaraní | 1:1 | ||||
| 2. Round | 26/07/2024 | Sportivo Trinidense | - | Guaraní | 1:2 | ||||
| 3. Round | 03/08/2024 | Guaraní | - | Libertad | 0:0 | ||||
| 4. Round | 07/08/2024 | Sportivo Ameliano | - | Guaraní | 2:2 |  |
|||
| 9. Round | 01/09/2024 | Guaraní | - | Cerro Porteño | 1:0 | |
|||
| 10. Round | 14/09/2024 | Tacuary | - | Guaraní | 1:2 | ||||
| 14. Round | 06/10/2024 | Libertad | - | Guaraní | 0:2 | |
|||
| 15. Round | 12/10/2024 | Guaraní | - | Sportivo Ameliano | 1:1 | ||||
| 16. Round | 21/10/2024 | 2 de Mayo | - | Guaraní | 1:2 | ||||
| 18. Round | 02/11/2024 | General Caballero DJLM | - | Guaraní | 0:0 | |
|||
| 19. Round | 10/11/2024 | Guaraní | - | Sol de América | 1:1 | ||||
| 20. Round | 16/11/2024 | Cerro Porteño | - | Guaraní | 1:2 | ||||
| 21. Round | 24/11/2024 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Round | 29/11/2024 | Club Nacional | - | Guaraní | 0:0 | |
Paraguay