| 1. Round | 16/07/2021 | Unión de Santa Fe II | - | Boca Juniors II | 1:0 | ||||
| 2. Round | 23/07/2021 | River Plate II | - | Unión de Santa Fe II | 2:0 | ||||
| 3. Round | 27/07/2021 | Unión de Santa Fe II | - | Banfield II | 0:1 | ||||
| 4. Round | 30/07/2021 | Lanús II | - | Unión de Santa Fe II | 2:1 | ||||
| 5. Round | 06/08/2021 | Unión de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
| 15. Round | 08/10/2021 | Unión de Santa Fe II | - | Platense II | 1:4 | ||||
| 16. Round | 14/10/2021 | Sarmiento de Junín II | - | Unión de Santa Fe II | 2:2 | ||||
| 17. Round | 18/10/2021 | Unión de Santa Fe II | - | Racing Club II | 1:1 | ||||
| 18. Round | 22/10/2021 | Independiente II | - | Unión de Santa Fe II | 2:0 | ||||
| 19. Round | 29/10/2021 | Unión de Santa Fe II | - | Rosario Central II | 0:0 | ||||
| 20. Round | 05/11/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 | ||||
| 21. Round | 17/11/2021 | Unión de Santa Fe II | - | Defensa y Justicia II | 1:1 | ||||
| 22. Round | 22/11/2021 | Arsenal de Sarandí II | - | Unión de Santa Fe II | 0:0 |
Argentina