| 1. Round | 28/08/2021 | PEC Zwolle [U21] | - | De Graafschap [U21] | 2:1 |  |
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| 2. Round | 11/09/2021 | De Graafschap [U21] | - | SBV Excelsior [U21] | 0:1 | ||||
| 3. Round | 18/09/2021 | Roda JC Kerkrade [U21] | - | De Graafschap [U21] | 3:3 | ||||
| 4. Round | 25/09/2021 | De Graafschap [U21] | - | FC Emmen [U21] | 1:1 | ||||
| 5. Round | 02/10/2021 | Vitesse [U21] | - | De Graafschap [U21] | 1:1 | ||||
| 6. Round | 16/10/2021 | Willem II [U21] | - | De Graafschap [U21] | 1:2 | ||||
| 7. Round | 23/10/2021 | De Graafschap [U21] | - | Alphense Boys [U21] | 2:1 | |
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| 8. Round | 30/10/2021 | De Graafschap [U21] | - | Vitesse [U21] | 6:0 |
Netherlands