| 1. Round | 07/01/2022 | Puebla FC [U18] | - | CF América [U18] | 0:1 dec. | ||||
| 3. Round | 22/01/2022 | CF América [U18] | - | Atlas Guadalajara [U18] | 0:0 |  |
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| 4. Round | 05/02/2022 | CF América [U18] | - | Atlético San Luis [U18] | 3:1 | ||||
| 6. Round | 20/02/2022 | CF América [U18] | - | CF Pachuca [U18] | 3:0 |  |
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| 9. Round | 05/03/2022 | CF Monterrey [U18] | - | CF América [U18] | 3:5 |  |
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| 10. Round | 12/03/2022 | Deportivo Guadalajara [U18] | - | CF América [U18] | 3:2 | ||||
| 11. Round | 20/03/2022 | CF América [U18] | - | Deportivo Toluca [U18] | 3:2 | ||||
| 12. Round | 02/04/2022 | Club Necaxa [U18] | - | CF América [U18] | 2:2 | |
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| 13. Round | 09/04/2022 | CF América [U18] | - | FC Juárez [U18] | 3:0 | ||||
| 14. Round | 15/04/2022 | Club Tijuana [U18] | - | CF América [U18] | 2:0 | |
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| 15. Round | 20/04/2022 | CF América [U18] | - | Club León [U18] | 5:1 | |
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| 16. Round | 23/04/2022 | UANL Tigres [U18] | - | CF América [U18] | 0:2 | ||||
| 17. Round | 30/04/2022 | CF América [U18] | - | Cruz Azul [U18] | 3:2 |
USA
Mexico