| 1. Round | 30/07/2022 | Tranmere Rovers | - | Stevenage FC | 1:2 |  |
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| 2. Round | 06/08/2022 | Mansfield Town | - | Tranmere Rovers | 1:0 | ||||
| 3. Round | 13/08/2022 | Tranmere Rovers | - | Gillingham FC | 3:0 | ||||
| 4. Round | 16/08/2022 | Hartlepool United | - | Tranmere Rovers | 0:0 | ||||
| 5. Round | 20/08/2022 | Newport County | - | Tranmere Rovers | 2:1 | ||||
| 6. Round | 27/08/2022 | Tranmere Rovers | - | Colchester United | 2:0 | ||||
| 7. Round | 03/09/2022 | Leyton Orient | - | Tranmere Rovers | 2:0 | ||||
| 9. Round | 13/09/2022 | Tranmere Rovers | - | Bradford City | 1:2 | |
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| 10. Round | 17/09/2022 | Salford City | - | Tranmere Rovers | 0:1 | ||||
| 11. Round | 24/09/2022 | Walsall FC | - | Tranmere Rovers | 0:1 | |
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| 12. Round | 01/10/2022 | Tranmere Rovers | - | Barrow AFC | 1:0 | ||||
| 23. Round | 26/12/2022 | Tranmere Rovers | - | Doncaster Rovers | 3:0 | ||||
| 26. Round | 07/01/2023 | Tranmere Rovers | - | Sutton United | 2:2 |
Scotland