| 5. Round | 06/08/2021 | Unión de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
| 6. Round | 13/08/2021 | Talleres de Córdoba II | - | San Lorenzo II | 1:0 | ||||
| 8. Round | 23/08/2021 | Estudiantes II | - | San Lorenzo II | 2:2 |  |
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| 9. Round | 30/08/2021 | San Lorenzo II | - | Patronato de Paraná II | 2:2 | ||||
| 10. Round | 05/09/2021 | Platense II | - | San Lorenzo II | 1:1 | ||||
| 11. Round | 10/09/2021 | San Lorenzo II | - | Racing Club II | 0:0 |
Argentina