| 2. Round | 26/01/2019 | Club Nacional | - | Guaraní | 0:2 |  |
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| 4. Round | 07/02/2019 | Club Nacional | - | Sportivo Luqueño | 0:1 |  |
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| 5. Round | 10/02/2019 | Deportivo Santaní | - | Club Nacional | 1:2 | ||||
| 1. Round | 13/02/2019 | Club Nacional | - | Club Olimpia | 2:4 |  |
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| 6. Round | 18/02/2019 | Club Nacional | - | Sol de América | 0:1 | ||||
| 7. Round | 22/02/2019 | Cerro Porteño | - | Club Nacional | 1:1 | |
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| 9. Round | 03/03/2019 | Deportivo Capiatá | - | Club Nacional | 1:0 | |
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| 8. Round | 27/03/2019 | Club Nacional | - | Libertad | 0:1 | |
Paraguay