| 2. Round | 09/02/2021 | Club Nacional | - | Sol de América | 1:0 | ||||
| 7. Round | 10/03/2021 | Club Olimpia | - | Club Nacional | 1:4 | ||||
| 8. Round | 13/03/2021 | River Plate | - | Club Nacional | 0:0 |  |
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| 10. Round | 02/04/2021 | Club Nacional | - | Guaraní | 2:0 | ||||
| 11. Round | 10/04/2021 | Sol de América | - | Club Nacional | 1:2 | ||||
| 12. Round | 17/04/2021 | Club Nacional | - | Sportivo Luqueño | 1:0 | ||||
| 13. Round | 26/04/2021 | Libertad | - | Club Nacional | 1:1 | ||||
| 14. Round | 30/04/2021 | Club Nacional | - | Guaireña FC | 1:3 | ||||
| 16. Round | 17/05/2021 | Club Nacional | - | Club Olimpia | 2:1 |
Paraguay